Toll-like receptors and fungal infections: the role of TLR2, TLR4 and MyD88 in paracoccidioidomycosis

FEMS Immunol Med Microbiol. 2008 Jun;53(1):1-7. doi: 10.1111/j.1574-695X.2008.00378.x. Epub 2008 Apr 1.

Abstract

The aim of this minireview is to present a concise view of the most important pattern recognition receptors used by the innate immune system to sense and control pathogen growth into host tissues. A brief review of the role of Toll-like receptors (TLRs) in fungal infections followed by some recent results on the function of TLR4, TLR2 and the MyD88 adaptor molecule in the pathogenesis of paracoccidioidomycosis are presented.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Immunity, Innate
  • Myeloid Differentiation Factor 88 / immunology*
  • Paracoccidioides / immunology*
  • Paracoccidioidomycosis / immunology*
  • Toll-Like Receptor 2 / immunology*
  • Toll-Like Receptor 4 / immunology*

Substances

  • Myd88 protein, mouse
  • Myeloid Differentiation Factor 88
  • Tlr2 protein, mouse
  • Tlr4 protein, mouse
  • Toll-Like Receptor 2
  • Toll-Like Receptor 4