A new peritoneal carcinomatosis model in cyclosporine immunosuppressed rats

Javed Akhter; Peng Yao; Loreena A Johnson; Steve M Riordan; David L Morris

A new peritoneal carcinomatosis model in cyclosporine immunosuppressed rats

Anticancer Res. 2008 Jan-Feb;28(1A):105-8.

Authors

Javed Akhter¹, Peng Yao, Loreena A Johnson, Steve M Riordan, David L Morris

Affiliation

¹ University of New South Wales, Department of Surgery, St. George Hospital, Sydney, Australia.

PMID: 18383831

Abstract

Colorectal cancer (CRC) cells (HT29) were injected into the intraperitoneal (i.p.) cavity of immunosuppressed male Sprague Dawley rats. Immunosuppression was achieved via a daily i.p. injection of cyclosporine 35 mg/kg/day. Three groups of rats (n = 6 per group) were injected with 20, 50 or 100 million HT29 cells. All animals developed tumours indicating that this animal model may prove useful for future research in human colorectal carcinomatosis.

MeSH terms

Animals
Cell Growth Processes / immunology
Colorectal Neoplasms / blood
Colorectal Neoplasms / immunology*
Colorectal Neoplasms / pathology
Cyclosporine / blood
Cyclosporine / pharmacology*
Disease Models, Animal
HT29 Cells
Humans
Immunocompromised Host
Immunosuppressive Agents / blood
Immunosuppressive Agents / pharmacology*
Male
Neoplasm Invasiveness
Peritoneal Neoplasms / blood
Peritoneal Neoplasms / immunology*
Peritoneal Neoplasms / pathology
Rats
Rats, Sprague-Dawley

Substances

Immunosuppressive Agents
Cyclosporine