Slice-selective images of free radicals in mice with modulated field gradient electron paramagnetic resonance (EPR) imaging

Magn Reson Med. 2008 Apr;59(4):885-90. doi: 10.1002/mrm.21547.

Abstract

Continuous wave (CW) electron paramagnetic resonance (EPR) imaging can be used to obtain slice-selective images of free radicals without measuring three-dimensional (3D) projection data. A method that incorporated a modulated magnetic field gradient (MFG) was combined with polar field gradients to select a slice in the subject noninvasively. The slice-selective in vivo EPR imaging of triarylmethyl radicals in the heads of live mice is reported. 3D surface-rendered images were successfully obtained from slice-selective images. In the experiment in mice, a slice thickness of 1.8 mm was achieved.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms*
  • Animals
  • Brain / anatomy & histology*
  • Brain / metabolism*
  • Electron Spin Resonance Spectroscopy / methods*
  • Free Radicals / metabolism*
  • Image Interpretation, Computer-Assisted / methods*
  • Male
  • Mice
  • Mice, Inbred ICR
  • Reactive Oxygen Species / metabolism*

Substances

  • Free Radicals
  • Reactive Oxygen Species