Clinical characteristics of schizotypal-related obsessive-compulsive disorder

Psychiatry Res. 2008 May 30;159(1-2):254-8. doi: 10.1016/j.psychres.2007.02.019. Epub 2008 Apr 18.

Abstract

In this study we compared 15 patients with DSM-IV obsessive-compulsive disorder (OCD) and schizotypal personality disorder (SPD) and 31 non-SPD OCD patients. OCD-SPD patients had poorer insight, more negative symptoms, lower functioning, more antipsychotic augmentation and more first-degree relatives with schizophrenia-spectrum disorders. A distinct clinical phenotype of OCD associated with SPD should be considered when investigating etiopathogenetic mechanisms.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Age of Onset
  • Antipsychotic Agents / therapeutic use
  • Comorbidity
  • Diagnostic and Statistical Manual of Mental Disorders
  • Family / psychology
  • Female
  • Genetic Predisposition to Disease / genetics
  • Humans
  • Israel / epidemiology
  • Logistic Models
  • Male
  • Mental Disorders / diagnosis
  • Mental Disorders / epidemiology
  • Obsessive-Compulsive Disorder / diagnosis*
  • Obsessive-Compulsive Disorder / epidemiology*
  • Obsessive-Compulsive Disorder / genetics
  • Phenotype
  • Psychiatric Status Rating Scales / statistics & numerical data
  • Schizophrenia / diagnosis
  • Schizophrenia / epidemiology
  • Schizophrenia / genetics
  • Schizophrenic Psychology
  • Schizotypal Personality Disorder / diagnosis*
  • Schizotypal Personality Disorder / epidemiology*
  • Schizotypal Personality Disorder / genetics
  • Severity of Illness Index

Substances

  • Antipsychotic Agents