Abstract
In this study we compared 15 patients with DSM-IV obsessive-compulsive disorder (OCD) and schizotypal personality disorder (SPD) and 31 non-SPD OCD patients. OCD-SPD patients had poorer insight, more negative symptoms, lower functioning, more antipsychotic augmentation and more first-degree relatives with schizophrenia-spectrum disorders. A distinct clinical phenotype of OCD associated with SPD should be considered when investigating etiopathogenetic mechanisms.
MeSH terms
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Adult
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Age of Onset
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Antipsychotic Agents / therapeutic use
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Comorbidity
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Diagnostic and Statistical Manual of Mental Disorders
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Family / psychology
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Female
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Genetic Predisposition to Disease / genetics
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Humans
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Israel / epidemiology
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Logistic Models
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Male
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Mental Disorders / diagnosis
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Mental Disorders / epidemiology
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Obsessive-Compulsive Disorder / diagnosis*
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Obsessive-Compulsive Disorder / epidemiology*
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Obsessive-Compulsive Disorder / genetics
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Phenotype
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Psychiatric Status Rating Scales / statistics & numerical data
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Schizophrenia / diagnosis
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Schizophrenia / epidemiology
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Schizophrenia / genetics
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Schizophrenic Psychology
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Schizotypal Personality Disorder / diagnosis*
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Schizotypal Personality Disorder / epidemiology*
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Schizotypal Personality Disorder / genetics
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Severity of Illness Index