Are hematopoietic stem cells generated in the placenta?

Cell Stem Cell. 2008 Mar 6;2(3):197-8. doi: 10.1016/j.stem.2008.02.013.

Abstract

In this issue of Cell Stem Cell, the origin of multipotent hematopoietic cells present in the placenta has been assessed in Ncx1(-/-) embryos lacking a functional heart and circulation. Rhodes and colleagues (Rhodes et al., 2008) found lymphoid progenitors in the placenta, as well as in dorsal aorta and yolk sac and vitelline vessels, indicating that they arose in situ.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cell Lineage / physiology
  • Core Binding Factor Alpha 2 Subunit / genetics
  • Core Binding Factor Alpha 2 Subunit / metabolism
  • Female
  • Hematopoiesis, Extramedullary / physiology
  • Hematopoietic Stem Cells / physiology*
  • Liver / cytology
  • Liver / embryology*
  • Mice
  • Mice, Knockout
  • Placenta / blood supply*
  • Placenta / cytology
  • Platelet Membrane Glycoprotein IIb / genetics
  • Platelet Membrane Glycoprotein IIb / metabolism
  • Pregnancy / physiology*
  • Sodium-Calcium Exchanger / genetics
  • Sodium-Calcium Exchanger / metabolism

Substances

  • Core Binding Factor Alpha 2 Subunit
  • NCX1 protein, mouse
  • Platelet Membrane Glycoprotein IIb
  • Runx1 protein, mouse
  • Sodium-Calcium Exchanger