LIS1 and spindle orientation in neuroepithelial cells

Jens C Schwamborn; Juergen A Knoblich

doi:10.1016/j.stem.2008.02.010

LIS1 and spindle orientation in neuroepithelial cells

Cell Stem Cell. 2008 Mar 6;2(3):193-4. doi: 10.1016/j.stem.2008.02.010.

Authors

Jens C Schwamborn¹, Juergen A Knoblich

Affiliation

¹ Institute of Molecular Biotechnology of Austrian Academy of Sciences, Dr. Bohr-Gasse 3, 1030 Vienna, Austria.

PMID: 18371441
DOI: 10.1016/j.stem.2008.02.010

Abstract

Asymmetric stem cell division is thought to require precise orientation of the mitotic spindle. However, a recent study in Cell (Yingling et al., 2008) analyzes the role of LIS1 in the developing mouse brain and shows that spindle orientation is more important during early, symmetric progenitor cell divisions than for later asymmetric divisions.

Publication types

Review

MeSH terms

1-Alkyl-2-acetylglycerophosphocholine Esterase / metabolism*
Animals
Brain / embryology*
Cell Division / physiology*
Mice
Microtubule-Associated Proteins / metabolism*
Neuroepithelial Cells / cytology
Neuroepithelial Cells / physiology*
Spindle Apparatus / physiology*
Stem Cells / cytology
Stem Cells / physiology*

Substances

Microtubule-Associated Proteins
1-Alkyl-2-acetylglycerophosphocholine Esterase
Pafah1b1 protein, mouse