Abstract
We have developed a new biosensor architecture, which is comprised of a polypeptide-peptide nucleic acid tri-block copolymer and which we have termed chimeric peptide beacons (CPB), that generates an optical output via a mechanism analogous to that employed in DNA-based molecular beacons.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Biosensing Techniques*
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DNA / chemistry*
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HIV Antibodies / analysis
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HIV Antigens / immunology
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Indicators and Reagents
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Nucleic Acid Conformation
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Peptide Nucleic Acids / chemistry*
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Peptides / chemistry*
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Spectrometry, Fluorescence
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gag Gene Products, Human Immunodeficiency Virus / immunology
Substances
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HIV Antibodies
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HIV Antigens
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Indicators and Reagents
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Peptide Nucleic Acids
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Peptides
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gag Gene Products, Human Immunodeficiency Virus
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p17 protein, Human Immunodeficiency Virus Type 1
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DNA