Chimeric peptide beacons: a direct polypeptide analog of DNA molecular beacons

Chem Commun (Camb). 2007 Dec 14:(46):4869-71. doi: 10.1039/b709776j.

Abstract

We have developed a new biosensor architecture, which is comprised of a polypeptide-peptide nucleic acid tri-block copolymer and which we have termed chimeric peptide beacons (CPB), that generates an optical output via a mechanism analogous to that employed in DNA-based molecular beacons.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Biosensing Techniques*
  • DNA / chemistry*
  • HIV Antibodies / analysis
  • HIV Antigens / immunology
  • Indicators and Reagents
  • Nucleic Acid Conformation
  • Peptide Nucleic Acids / chemistry*
  • Peptides / chemistry*
  • Spectrometry, Fluorescence
  • gag Gene Products, Human Immunodeficiency Virus / immunology

Substances

  • HIV Antibodies
  • HIV Antigens
  • Indicators and Reagents
  • Peptide Nucleic Acids
  • Peptides
  • gag Gene Products, Human Immunodeficiency Virus
  • p17 protein, Human Immunodeficiency Virus Type 1
  • DNA