Lithium thiazolidine-4-carboxylate: synthesis, spectroscopic characterization and preliminary in vitro cytotoxic studies in human HeLa cells

Spectrochim Acta A Mol Biomol Spectrosc. 2008 Dec 1;71(3):929-31. doi: 10.1016/j.saa.2008.02.013. Epub 2008 Feb 13.

Abstract

A new water-soluble lithium salt of thiazolidine-4-carboxylic acid was synthesized and characterized by chemical and spectroscopic techniques. Elemental and mass spectrometric (ESI-MS) analyses of the solid compound fit to the composition LiC(4)H(6)NSO(2). (1)H, (13)C nuclear magnetic resonance (NMR), [(1)H-(15)N] NMR and infrared (IR) analyses permitted to elucidate the structure of the compound. Biological activity was evaluated by cytotoxic analysis using HeLa cells. Determination of cell death was assessed using a tetrazolium salt colorimetric assay, which reflects the cells viability.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Death / drug effects
  • HeLa Cells
  • Humans
  • Lithium Compounds / chemical synthesis*
  • Lithium Compounds / chemistry*
  • Lithium Compounds / toxicity
  • Magnetic Resonance Spectroscopy
  • Spectrophotometry, Infrared
  • Thiazolidines / chemical synthesis*
  • Thiazolidines / chemistry*
  • Thiazolidines / toxicity

Substances

  • Lithium Compounds
  • Thiazolidines
  • thiazolidine-4-carboxylic acid