Reirradiation, surgery and IORT for recurrent rectal cancer in previously irradiated patients

Maarten Vermaas; Joost J M E Nuyttens; Floris T J Ferenschild; Cornelis Verhoef; Alexander M M Eggermont; Johannes H W de Wilt

doi:10.1016/j.radonc.2008.02.021

Reirradiation, surgery and IORT for recurrent rectal cancer in previously irradiated patients

Radiother Oncol. 2008 Jun;87(3):357-60. doi: 10.1016/j.radonc.2008.02.021. Epub 2008 Mar 18.

Authors

Maarten Vermaas¹, Joost J M E Nuyttens, Floris T J Ferenschild, Cornelis Verhoef, Alexander M M Eggermont, Johannes H W de Wilt

Affiliation

¹ Department of Surgical Oncology, Erasmus MC -- Daniel den Hoed Cancer Centre, Rotterdam, The Netherlands.

PMID: 18353474
DOI: 10.1016/j.radonc.2008.02.021

Abstract

A total of 11 patients with recurrent rectal cancer who had been previously irradiated were treated with preoperative reirradiation (median dose 30Gy), surgery and IORT. This treatment was related with high morbidity, a short pain-free survival (5 months) and poor local control (27% after 3 years), although some patients have long-term distant control and survival.

MeSH terms

Adult
Aged
Combined Modality Therapy
Disease-Free Survival
Female
Humans
Intraoperative Period
Male
Middle Aged
Neoplasm Recurrence, Local / radiotherapy*
Neoplasm Recurrence, Local / surgery
Postoperative Complications
Radiotherapy Dosage
Radiotherapy, Adjuvant
Rectal Neoplasms / radiotherapy*
Rectal Neoplasms / surgery