Abstract
Background:
Combined diphtheria-tetanus-whole-cell pertussis (DTPw) vaccines remain the cornerstone of many childhood vaccination programs. Larger DTPw-based combination vaccines facilitate high coverage and protection against other childhood pathogens, such as hepatitis B (HBV) and Haemophilus influenzae type b (Hib). Such vaccines have been available since the mid-1990s (Tritanrix-HBV and Tritanrix-HBV/Hib; GlaxoSmithKline [GSK] Biologicals), demonstrating excellent immunogenicity in various schedules. In order to address growing demand for DTPw-based vaccines, GSK Biologicals have developed the Zilbrix range using a new DTPw antigen source and containing reduced quantities of polyribosylribitol phosphate [PRP].
Objective:
This article presents clinical trial results for both DTPw-based vaccines.
Methods:
GSK Biologicals provided a comprehensive data package, which was supplemented with a Medline literature search.
Conclusion:
New antigen sources and reduced PRP will ensure the continued supply of DTPw-based combination vaccines for vital global mass vaccination campaigns.
MeSH terms
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Antibodies, Bacterial / blood
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Antigens, Bacterial / immunology
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Bacterial Capsules
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Child
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Child, Preschool
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Clinical Trials as Topic
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Diphtheria-Tetanus-Pertussis Vaccine / administration & dosage
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Diphtheria-Tetanus-Pertussis Vaccine / adverse effects
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Diphtheria-Tetanus-Pertussis Vaccine / immunology*
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Global Health
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Haemophilus Vaccines / administration & dosage
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Haemophilus Vaccines / adverse effects
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Haemophilus Vaccines / immunology*
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Hepatitis B Antibodies / blood
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Hepatitis B Antigens / immunology
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Hepatitis B Vaccines / administration & dosage
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Hepatitis B Vaccines / adverse effects
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Hepatitis B Vaccines / immunology*
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Humans
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Immunization Schedule
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Immunization, Secondary
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Infant
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Infant, Newborn
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Mass Vaccination*
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Polysaccharides / immunology
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Polysaccharides, Bacterial / administration & dosage
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Polysaccharides, Bacterial / adverse effects
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Polysaccharides, Bacterial / immunology*
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Treatment Outcome
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Vaccines, Combined / administration & dosage
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Vaccines, Combined / adverse effects
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Vaccines, Combined / immunology*
Substances
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Antibodies, Bacterial
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Antigens, Bacterial
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Diphtheria-Tetanus-Pertussis Vaccine
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Haemophilus Vaccines
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Haemophilus influenzae type b polysaccharide vaccine
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Hepatitis B Antibodies
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Hepatitis B Antigens
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Hepatitis B Vaccines
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Polysaccharides
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Polysaccharides, Bacterial
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Tritanrix-HepB vaccine
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Vaccines, Combined
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polyribitol phosphate