Clinical experience with DTPw-HBV and DTPw-HBV/Hib combination vaccines

Expert Opin Biol Ther. 2008 Apr;8(4):503-13. doi: 10.1517/14712598.8.4.503.

Abstract

Background: Combined diphtheria-tetanus-whole-cell pertussis (DTPw) vaccines remain the cornerstone of many childhood vaccination programs. Larger DTPw-based combination vaccines facilitate high coverage and protection against other childhood pathogens, such as hepatitis B (HBV) and Haemophilus influenzae type b (Hib). Such vaccines have been available since the mid-1990s (Tritanrix-HBV and Tritanrix-HBV/Hib; GlaxoSmithKline [GSK] Biologicals), demonstrating excellent immunogenicity in various schedules. In order to address growing demand for DTPw-based vaccines, GSK Biologicals have developed the Zilbrix range using a new DTPw antigen source and containing reduced quantities of polyribosylribitol phosphate [PRP].

Objective: This article presents clinical trial results for both DTPw-based vaccines.

Methods: GSK Biologicals provided a comprehensive data package, which was supplemented with a Medline literature search.

Conclusion: New antigen sources and reduced PRP will ensure the continued supply of DTPw-based combination vaccines for vital global mass vaccination campaigns.

Publication types

  • Review

MeSH terms

  • Antibodies, Bacterial / blood
  • Antigens, Bacterial / immunology
  • Bacterial Capsules
  • Child
  • Child, Preschool
  • Clinical Trials as Topic
  • Diphtheria-Tetanus-Pertussis Vaccine / administration & dosage
  • Diphtheria-Tetanus-Pertussis Vaccine / adverse effects
  • Diphtheria-Tetanus-Pertussis Vaccine / immunology*
  • Global Health
  • Haemophilus Vaccines / administration & dosage
  • Haemophilus Vaccines / adverse effects
  • Haemophilus Vaccines / immunology*
  • Hepatitis B Antibodies / blood
  • Hepatitis B Antigens / immunology
  • Hepatitis B Vaccines / administration & dosage
  • Hepatitis B Vaccines / adverse effects
  • Hepatitis B Vaccines / immunology*
  • Humans
  • Immunization Schedule
  • Immunization, Secondary
  • Infant
  • Infant, Newborn
  • Mass Vaccination*
  • Polysaccharides / immunology
  • Polysaccharides, Bacterial / administration & dosage
  • Polysaccharides, Bacterial / adverse effects
  • Polysaccharides, Bacterial / immunology*
  • Treatment Outcome
  • Vaccines, Combined / administration & dosage
  • Vaccines, Combined / adverse effects
  • Vaccines, Combined / immunology*

Substances

  • Antibodies, Bacterial
  • Antigens, Bacterial
  • Diphtheria-Tetanus-Pertussis Vaccine
  • Haemophilus Vaccines
  • Haemophilus influenzae type b polysaccharide vaccine
  • Hepatitis B Antibodies
  • Hepatitis B Antigens
  • Hepatitis B Vaccines
  • Polysaccharides
  • Polysaccharides, Bacterial
  • Tritanrix-HepB vaccine
  • Vaccines, Combined
  • polyribitol phosphate