Bovicin HC5, a lantibiotic produced by Streptococcus bovis HC5, catalyzes the efflux of intracellular potassium but not ATP

Antimicrob Agents Chemother. 2008 Jun;52(6):2247-9. doi: 10.1128/AAC.00109-08. Epub 2008 Mar 17.

Abstract

Bovicin HC5, a broad-spectrum lantibiotic produced by Streptococcus bovis HC5, catalyzed the efflux of intracellular potassium from Streptococcus bovis JB1, a sensitive strain. The level of ATP also decreased, but this decline appeared to be caused by the activity of the F(1)F(0) ATPase rather than efflux per se.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adenosine Triphosphate / metabolism*
  • Anti-Bacterial Agents / pharmacology*
  • Bacteriocins / biosynthesis
  • Bacteriocins / metabolism
  • Bacteriocins / pharmacology*
  • Culture Media
  • Glucose / metabolism
  • Potassium / metabolism*
  • Proton-Translocating ATPases / metabolism
  • Streptococcus bovis / classification
  • Streptococcus bovis / drug effects*
  • Streptococcus bovis / growth & development
  • Streptococcus bovis / metabolism*

Substances

  • Anti-Bacterial Agents
  • Bacteriocins
  • Culture Media
  • bovicin HC5, Streptococcus bovis HC5
  • Adenosine Triphosphate
  • Proton-Translocating ATPases
  • Glucose
  • Potassium