"Unraveling the tail" of how SRPK1 phosphorylates ASF/SF2

Daniel Y L Mao; Derek F Ceccarelli; Frank Sicheri

doi:10.1016/j.molcel.2008.02.009

"Unraveling the tail" of how SRPK1 phosphorylates ASF/SF2

Mol Cell. 2008 Mar 14;29(5):535-7. doi: 10.1016/j.molcel.2008.02.009.

Authors

Daniel Y L Mao¹, Derek F Ceccarelli, Frank Sicheri

Affiliation

¹ Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada.

PMID: 18342599
DOI: 10.1016/j.molcel.2008.02.009

Abstract

In this issue of Molecular Cell, Ngo et al. (2008) describe the crystal structure of the SRPK1 protein kinase in complex with its substrate, the spliceosome factor ASF/SF2, providing an unprecedented view of multiple targeting mechanisms in action on a single substrate.

Publication types

Comment

MeSH terms

Animals
Humans
Mice
Nuclear Proteins / chemistry*
Nuclear Proteins / genetics
Nuclear Proteins / metabolism*
Phosphorylation
Protein Serine-Threonine Kinases / chemistry*
Protein Serine-Threonine Kinases / genetics
Protein Serine-Threonine Kinases / metabolism*
Protein Structure, Tertiary*
RNA-Binding Proteins
Serine-Arginine Splicing Factors
Substrate Specificity

Substances

Nuclear Proteins
RNA-Binding Proteins
Serine-Arginine Splicing Factors
SRPK1 protein, human
Protein Serine-Threonine Kinases