Abstract
Three independent studies of tight glucose control were recently stopped prematurely due to an excess mortality in the intensive treatment arm. This commentary briefly discusses the potential mechanisms and reminds the potential benefits of physiological stress hyperglycemia.
MeSH terms
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Blood Glucose / drug effects
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Diabetes Mellitus, Type 2 / drug therapy*
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Hospital Mortality*
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Humans
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Hypoglycemic Agents / adverse effects*
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Hypoglycemic Agents / pharmacology
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Hypoglycemic Agents / therapeutic use
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Insulin / adverse effects*
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Insulin / pharmacology
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Insulin / therapeutic use
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Intensive Care Units
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Multicenter Studies as Topic
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Randomized Controlled Trials as Topic
Substances
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Blood Glucose
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Hypoglycemic Agents
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Insulin