Abstract
Nineteen new sesterterpenoids and eight known compounds were isolated from the sponge Sarcotragus sp. collected from Soheuksan Island, Korea. The structures of these compounds were determined to be linear sesterterpenoids containing furan or related oxygenated functionalities on the basis of combined chemical and spectroscopic analyses. In addition, the configurations of several previously undetermined compounds were assigned. Several compounds exhibited moderate to major antibacterial activity (compounds 1- 3, 17, 18) and cytotoxicity ( 3, 11, 12) against the K562 cell line and inhibitory activity against isocitrate lyase ( 6, 13).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Aspergillus fumigatus / drug effects
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Candida albicans / enzymology
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Drug Screening Assays, Antitumor
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Humans
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Isocitrate Lyase / antagonists & inhibitors*
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K562 Cells
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Korea
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Methicillin Resistance / drug effects
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Microbial Sensitivity Tests
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Molecular Structure
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Porifera / chemistry*
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Sesterterpenes / chemistry
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Sesterterpenes / isolation & purification*
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Sesterterpenes / pharmacology
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Staphylococcus aureus / drug effects
Substances
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Anti-Bacterial Agents
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Antineoplastic Agents
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Sesterterpenes
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Isocitrate Lyase