[Molecular mechanisms for intracellular parasitisation and exclusion in macrophage infected with Mycobacterium leprae]

Kazunari Tanigawa; Koichi Suzuki; Akira Kawashima; Masayo Mishima; Huhehasi Wu; Takeshi Akama; Fumihiko Takeshita; Norihisa Ishii

doi:10.5025/hansen.77.57

[Molecular mechanisms for intracellular parasitisation and exclusion in macrophage infected with Mycobacterium leprae]

Nihon Hansenbyo Gakkai Zasshi. 2008 Feb;77(1):57-61. doi: 10.5025/hansen.77.57.

[Article in Japanese]

Authors

Kazunari Tanigawa¹, Koichi Suzuki, Akira Kawashima, Masayo Mishima, Huhehasi Wu, Takeshi Akama, Fumihiko Takeshita, Norihisa Ishii

Affiliation

¹ Department of Bioregulation, Leprosy Research Center, National Institute of Infectious Diseases, Higashimurayama, Tokyo, Japan. tanigawa@nih.go.jp

PMID: 18341026
DOI: 10.5025/hansen.77.57

Abstract

It was previously demonstrated that TLR2 and CORO1A (TACO, Coronin 1, p57) localize phagosome membrane of macrophage. However, the functional relationship between TLR2 and CORO1A was not known. We show here that there is a functional counteraction between TLR2 and CORO1A.

Publication types

English Abstract

MeSH terms

Cells, Cultured
Humans
Leprosy* / genetics
Leprosy* / microbiology
Macrophages / immunology*
Macrophages / microbiology*
Microfilament Proteins / physiology*
Mycobacterium leprae*
Phagosomes / genetics
Signal Transduction / physiology
Skin / cytology
Toll-Like Receptor 2 / physiology*

Substances

Microfilament Proteins
Toll-Like Receptor 2
coronin proteins