Suitable imaging methods to reliably rule out coronary artery disease as the underlying condition might be beneficially applied in the workup of patients with acute chest pain. The temporal and spatial resolution of computed tomgraphy and electron beam computed tomography has seen continuous improvements over the past years. Current scanner generations permit relatively reliable visualization of the coronary arteries and several studies have demonstrated a high negative predictive value to rule out coronary artery stenoses. Even though applications in the context of acute coronary syndromes have not yet been specifically evaluated, it seems likely that computed tomography imaging may develop into a tool that can be integrated into the workflow in chest pain centers once appropriate studies have been performed.