Catalytic alkene cyclohydroamination via an imido mechanism

Chem Commun (Camb). 2008 Mar 28:(12):1422-4. doi: 10.1039/b718373a. Epub 2008 Feb 15.

Abstract

Chiral-at-metal half-sandwich diamide complexes catalyse enantioselective cyclohydroamination of aminoalkenes at unexpectedly high rates given their high coordination number and steric bulk; substantial evidence is presented which argues against the established sigma-bond insertion process and is strongly indicative of an imido [2+2] cycloaddition mechanism.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkenes / chemistry*
  • Amination
  • Catalysis
  • Crystallography, X-Ray
  • Cyclization
  • Imines / chemistry*
  • Magnetic Resonance Spectroscopy / methods
  • Models, Molecular
  • Molecular Structure
  • Organometallic Compounds / chemical synthesis*
  • Organometallic Compounds / chemistry
  • Stereoisomerism
  • Zirconium / chemistry*

Substances

  • Alkenes
  • Imines
  • Organometallic Compounds
  • Zirconium