Abstract
Some new hydrazono 5a,b, thiosemicarbazono 6a-c, and oximo chromenes 7a-c were prepared via the reaction of the corresponding beta-chlorocarbaldehyde 3 with hydrazine, aromatic hydrazine, thiosemicarbazide and hydroxylamine hydrochloride, respectively. In addition, ether derivatives 8a-h were prepared from the corresponding aldoximes 7a-c. The new products were tested for anti-inflammatory and ulcerogenic score activities compared to indomethacin.
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Anti-Inflammatory Agents, Non-Steroidal / toxicity
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Benzopyrans / chemical synthesis*
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Benzopyrans / chemistry
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Benzopyrans / pharmacology
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Benzopyrans / toxicity
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Drug Design*
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Drug Evaluation, Preclinical
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Edema / drug therapy
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Edema / physiopathology
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Female
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Lethal Dose 50
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Male
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Mice
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Molecular Structure
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Rats
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Rats, Sprague-Dawley
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Rats, Wistar
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Stomach Ulcer / chemically induced*
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Benzopyrans