Synthesis of UDP-glucose derivatives modified at the 3-OH as potential chain terminators of beta-glucan biosynthesis

Carbohydr Res. 2008 May 5;343(6):1012-22. doi: 10.1016/j.carres.2008.01.031. Epub 2008 Feb 2.

Abstract

A series of UDP-D-glucose derivatives and precursors that have been modified at C-3 were synthesised from D-glucose as potential chain terminators of beta-glucan biosynthesis. None of the UDP-derivatives or the precursors tested displayed significant anti-fungal activity in a series of germination assays on the dermatophyte Trichophyton rubrum.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antifungal Agents / chemical synthesis*
  • Antifungal Agents / chemistry
  • Antifungal Agents / pharmacology
  • Trichophyton / drug effects*
  • Trichophyton / physiology
  • Uridine Diphosphate Glucose / chemical synthesis*
  • Uridine Diphosphate Glucose / chemistry
  • Uridine Diphosphate Glucose / pharmacology
  • beta-Glucans / antagonists & inhibitors
  • beta-Glucans / metabolism*

Substances

  • Antifungal Agents
  • beta-Glucans
  • beta-1,3-glucan
  • Uridine Diphosphate Glucose