Abstract
A series of UDP-D-glucose derivatives and precursors that have been modified at C-3 were synthesised from D-glucose as potential chain terminators of beta-glucan biosynthesis. None of the UDP-derivatives or the precursors tested displayed significant anti-fungal activity in a series of germination assays on the dermatophyte Trichophyton rubrum.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antifungal Agents / chemical synthesis*
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Antifungal Agents / chemistry
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Antifungal Agents / pharmacology
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Trichophyton / drug effects*
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Trichophyton / physiology
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Uridine Diphosphate Glucose / chemical synthesis*
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Uridine Diphosphate Glucose / chemistry
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Uridine Diphosphate Glucose / pharmacology
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beta-Glucans / antagonists & inhibitors
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beta-Glucans / metabolism*
Substances
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Antifungal Agents
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beta-Glucans
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beta-1,3-glucan
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Uridine Diphosphate Glucose