"Click-fluors": modular fluorescent saccharide sensors based on a 1,2,3-triazole ring

J Org Chem. 2008 Apr 4;73(7):2871-4. doi: 10.1021/jo702584u. Epub 2008 Mar 13.

Abstract

A carbohydrate sensing "click-fluor" is reported which displays a nontypical binding preference with sample saccharides. That a fluorescent sensor is generated as a result of triazole formation (click reaction), rather than simply bringing the sensor and reporter units together via a triazole linkage, and the potential applicability of the wide range of easily accessible acetylene units means a simple strategy for the development of modular fluorescent sensor arrays for rapid screening of target saccharides will be available.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Boronic Acids / chemical synthesis
  • Boronic Acids / chemistry*
  • Carbohydrates / chemistry*
  • Crystallography, X-Ray
  • Fluorescent Dyes / chemistry*
  • Models, Molecular
  • Molecular Structure
  • Stereoisomerism
  • Triazoles / chemistry*

Substances

  • Boronic Acids
  • Carbohydrates
  • Fluorescent Dyes
  • Triazoles