Fluorescent magnetic nanohybrids as multimodal imaging agents for human epithelial cancer detection

Biomaterials. 2008 Jun;29(16):2548-55. doi: 10.1016/j.biomaterials.2007.12.036. Epub 2008 Mar 10.

Abstract

Cetuximab conjugated fluorescent magnetic nanohybrids (CET-FMNHs) were synthesized for detection of human epithelial cancer via magnetic resonance (MR) and optical imaging. Spherical FMNHs consist of MnFe(2)O(4) magnetic nanocrystals encapsulated in pyrene-labeled PCL-b-PMAA as a surfactant prepared by a nano-emulsion method. FMNHs demonstrated excellent colloidal stability and biocompatibility for biomedical application. Antibody conjugated fluorescent magnetic nanohybrids (CET-FMNHs) served as effective agents for both magnetic resonance (MR) and fluorescence optical imaging of cancer cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Monoclonal*
  • Antibodies, Monoclonal, Humanized
  • Cell Line, Tumor
  • Cetuximab
  • Epithelial Cells / pathology*
  • ErbB Receptors
  • Flow Cytometry
  • Fluorescent Dyes*
  • Humans
  • Magnetic Resonance Imaging
  • Microscopy, Fluorescence
  • Nanoparticles*
  • Polyesters / chemical synthesis
  • Polymethacrylic Acids / chemical synthesis
  • Pyrenes / chemical synthesis

Substances

  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Humanized
  • Fluorescent Dyes
  • Polyesters
  • Polymethacrylic Acids
  • Pyrenes
  • polycaprolactone
  • ErbB Receptors
  • Cetuximab