Fibrosis in systemic sclerosis

Rheum Dis Clin North Am. 2008 Feb;34(1):115-43; vii. doi: 10.1016/j.rdc.2007.11.002.

Abstract

This article reviews current understanding of the pathophysiology of fibrosis in systemic sclerosis. It highlights recent discoveries, insights, and emerging research, and potential opportunities for the development of targeted antifibrotic therapies.

Publication types

  • Review

MeSH terms

  • Animals
  • Collagen / metabolism*
  • Disease Models, Animal
  • Fibroblasts / physiology
  • Fibrosis / etiology
  • Fibrosis / pathology
  • Fibrosis / physiopathology
  • Humans
  • Mice
  • Pericytes / physiology
  • Scleroderma, Systemic / diagnosis
  • Scleroderma, Systemic / physiopathology*

Substances

  • Collagen