Abstract
Bioassay-guided fractionation of extracts of various plants, marine organisms, and microorganisms has led to the discovery of new natural sources of a number of known compounds that have significant biological activity. The isolation of interesting and valuable cancer cell growth inhibitors including majusculamide C ( 1), axinastatin 5 ( 5), bengazoles A ( 6), B ( 7), and E ( 8), manzamine A ( 10), jaspamide ( 11), and neoechinulin A ( 19) has been summarized.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology*
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Carbazoles / chemistry
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Carbazoles / isolation & purification
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Carbazoles / pharmacology*
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Depsipeptides / chemistry
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Depsipeptides / isolation & purification
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Depsipeptides / pharmacology*
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Drug Screening Assays, Antitumor
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Indole Alkaloids / chemistry
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Indole Alkaloids / isolation & purification
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Indole Alkaloids / pharmacology*
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Marine Biology
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Molecular Structure
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Oxazoles / chemistry
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Oxazoles / isolation & purification
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Oxazoles / pharmacology*
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Peptides, Cyclic / chemistry
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Peptides, Cyclic / isolation & purification
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Peptides, Cyclic / pharmacology*
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Piperazines / chemistry
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Piperazines / isolation & purification
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Piperazines / pharmacology*
Substances
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Antineoplastic Agents
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Carbazoles
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Depsipeptides
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Indole Alkaloids
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Oxazoles
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Peptides, Cyclic
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Piperazines
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axinastatin 5
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bengazole A
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bengazole B
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bengazole E
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neoechinulin A
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jasplakinolide
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manzamine A
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majusculamide C