Abstract
A library of 17 novel estrogen analogues 3 and 4 containing different substituents at rings A and D (steroid nomenclature) was prepared in a five- to seven-step synthesis. The key transformation is a Sonogashira-coupling of cyclic vinyl iodides of type 7 or 8 with phenylacetylenes of type 9. Reduction of the keto function in 3 led to the estradiol analogue 5.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Estradiol / analogs & derivatives*
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Estradiol / chemical synthesis*
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Estradiol / chemistry
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Estrone / analogs & derivatives*
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Estrone / chemical synthesis*
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Estrone / chemistry
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Molecular Conformation
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Small Molecule Libraries / chemical synthesis*
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Stereoisomerism
Substances
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Small Molecule Libraries
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Estrone
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Estradiol