Efficient palladium-catalyzed synthesis of 3-aryl-4-indolylmaleimides

Org Biomol Chem. 2008 Mar 21;6(6):992-7. doi: 10.1039/b719160j. Epub 2008 Feb 14.

Abstract

Improved palladium catalysts for the Suzuki coupling of 3-bromo-1-methyl-4-(2-methyl-3-indolyl)maleimide have been developed. The coupling of both aryl- and heteroarylboronic acids proceeds smoothly in good to excellent yields at low catalyst loading.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Boron Compounds / chemistry
  • Catalysis
  • Indoles / chemical synthesis*
  • Indoles / chemistry
  • Maleimides / chemical synthesis*
  • Maleimides / chemistry
  • Molecular Structure
  • Organophosphorus Compounds / chemistry
  • Palladium / chemistry*

Substances

  • 3-bromo-1-methyl-4-(2-methylindolyl)maleimide
  • Boron Compounds
  • Indoles
  • Maleimides
  • Organophosphorus Compounds
  • Palladium