Amphotericin B-deoxycholate overdose due to administration error in pediatric patients

Med Mycol. 2008 Mar;46(2):185-7. doi: 10.1080/13693780701658280.

Abstract

Due to the similarity of their generic names, the use of amphotericin B-deoxycholate and liposomal amphotericin B could cause confusion in daily practice. We report two cases of amphotericin B-deoxycholate overdose in infants due to administration errors which raises the issue that the use of this antifungal agent should be questioned because of its severe side effects.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Amphotericin B / administration & dosage
  • Amphotericin B / adverse effects
  • Amphotericin B / poisoning*
  • Amphotericin B / therapeutic use
  • Antifungal Agents / administration & dosage
  • Antifungal Agents / poisoning*
  • Chemistry, Pharmaceutical
  • Deoxycholic Acid / administration & dosage
  • Deoxycholic Acid / adverse effects
  • Deoxycholic Acid / poisoning*
  • Drug Combinations
  • Drug Overdose
  • Fatal Outcome
  • Humans
  • Infant
  • Medication Errors*

Substances

  • Antifungal Agents
  • Drug Combinations
  • Deoxycholic Acid
  • Amphotericin B
  • amphotericin B, deoxycholate drug combination