Abstract
We evaluated the neurotrophic activity of dietary polyphenols by using primary cultures of fetal rat hippocampal neurons in a serum-free medium. Among the tested compounds, chlorogenic acid and its metabolite, m-coumaric acid, together with catechins and flavanone, were found to promote neuronal differentiation comparable to the phytochemical, honokiol, which has been reported to show potent neurotrophic activity. The present findings may contribute to the development of further neurotrophic studies on dietary polyphenols and their metabolites.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Catechin / pharmacology
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Cell Differentiation / drug effects
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Cells, Cultured
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Chlorogenic Acid / pharmacology*
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Coumaric Acids / pharmacology*
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Embryo, Mammalian / cytology
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Flavanones / pharmacology
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Flavonoids / pharmacology
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Hippocampus / cytology*
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Hippocampus / embryology
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Neurites / drug effects*
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Neurons / cytology
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Neurons / drug effects*
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Neurons / ultrastructure
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Phenols / pharmacology
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Polyphenols
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Rats
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Rats, Sprague-Dawley
Substances
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Coumaric Acids
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Flavanones
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Flavonoids
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Phenols
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Polyphenols
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Chlorogenic Acid
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Catechin
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flavanone