Synthesis of 1-{4-[4-(adamant-1-yl)phenoxymethyl]-2-(4-bromophenyl)- 1,3-dioxolan-2-ylmethyl}imidazole with expected antifungal and antibacterial activity

Acta Pol Pharm. 2007 Nov-Dec;64(6):535-41.

Authors

Dariusz A Płachta¹, Andrzej M Baranowski, Agnieszka E Laudy, Bohdan J Starościak, Jerzy Kleps

Affiliation

¹ Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Str., 02-097 Warsaw, Poland.

PMID: 18323248

Abstract

A multistep synthesis of a new analogue of ketoconazole, which was expected to show antifungal and antibacterial activity, has been described.

MeSH terms

Adamantane / analogs & derivatives*
Adamantane / chemical synthesis
Adamantane / pharmacology
Anti-Bacterial Agents / chemical synthesis
Anti-Bacterial Agents / pharmacology*
Antifungal Agents / chemical synthesis
Antifungal Agents / pharmacology*
Drug Interactions
Fungi / drug effects
Gram-Negative Bacteria / drug effects
Gram-Positive Bacteria / drug effects
Imidazoles / chemical synthesis
Imidazoles / pharmacology*
Microbial Sensitivity Tests

Substances

1-(4-(4-(adamant-1-yl)phenoxymethyl)-2-(4-bromophenyl)-1,3-dioxolan-2-ylmethyl)imidazole
Anti-Bacterial Agents
Antifungal Agents
Imidazoles
Adamantane