Synthesis and preliminary evaluation of aminoalkanol derivatives of selected azatricycloundecane system for binding with beta-adrenergic and 5HT1A and 5HT2A receptors

Acta Pol Pharm. 2007 Nov-Dec;64(6):527-33.

Abstract

A series of aminoalkanol derivatives of 8,11-dimethyl-3,5-dioxo-4-azatricyclo[5.2.2.0(2,6)] undec-8-en-1-yl acetate and 1,11-dimethyl-4-azatricyclo[5.2.2.0(2,6)]undecane-3,5,8-trione was prepared. The pharmacological profile of selected compounds was evaluated for affinity to beta-adrenoreceptors and serotoninergic receptors (5HT1A and 5HT2A).

MeSH terms

  • Amino Alcohols / chemical synthesis
  • Amino Alcohols / pharmacology*
  • Animals
  • Binding Sites
  • Cerebral Cortex / metabolism
  • In Vitro Techniques
  • Radioligand Assay
  • Rats
  • Receptor, Serotonin, 5-HT1A / metabolism*
  • Receptor, Serotonin, 5-HT2A / metabolism*
  • Receptors, Adrenergic, beta / metabolism*
  • Structure-Activity Relationship

Substances

  • Amino Alcohols
  • Receptor, Serotonin, 5-HT2A
  • Receptors, Adrenergic, beta
  • Receptor, Serotonin, 5-HT1A