Recent field observations suggest that ammonium salts of organic acids may be very important in accounting for aerosols' properties in many environments. In this study we present laboratory experiments and calculations on the influence of ammonia reaction with organic aerosol components and its effect upon their (1) subsaturation hygroscopic growth (HG) and (2) supersaturation cloud condensation nuclei (CCN) activity. By using adipic acid (slightly soluble), citric acid (soluble), and di(ethylene glycol) monovinyl ether (DEGMVE, nonacidic compound) aerosols we show the feasibility and importance of atmospherically relevant acid-base neutralization by ammonia for different organic species. It is suggested that the formation of ammonium salts due to reaction of ammonia with slightly soluble organic acids (such as adipic acid) can affect the CCN activity and hygroscopic growth of aerosols with a significant organic component. It is further confined that the reaction involves carboxylic groups, it requires presence of water in the aerosol, and that the effects are stronger for less soluble organic acids.