Antifungal and antimycobacterial activity of 1-(3,5-diaryl-4,5-dihydro-1H-pyrazol-4-yl)-1H-imidazole derivatives

Daniele Zampieri; Maria Grazia Mamolo; Erik Laurini; Giuditta Scialino; Elena Banfi; Luciano Vio

doi:10.1016/j.bmc.2008.02.055

Antifungal and antimycobacterial activity of 1-(3,5-diaryl-4,5-dihydro-1H-pyrazol-4-yl)-1H-imidazole derivatives

Bioorg Med Chem. 2008 Apr 15;16(8):4516-22. doi: 10.1016/j.bmc.2008.02.055. Epub 2008 Feb 21.

Authors

Daniele Zampieri¹, Maria Grazia Mamolo, Erik Laurini, Giuditta Scialino, Elena Banfi, Luciano Vio

Affiliation

¹ Department of Pharmaceutical Sciences, Piazzale Europa 1, University of Trieste, I-34127 Trieste, Italy.

PMID: 18321714
DOI: 10.1016/j.bmc.2008.02.055

Abstract

1-(3,5-Diaryl-4,5-dihydro-1H-pyrazol-4-yl)-1H-imidazole derivatives were synthesized and tested for their in vitro antifungal and antimycobacterial activities. These imidazole derivatives showed an excellent antifungal activity against a clinical strain of Candida albicans and an interesting antitubercular activity against Mycobacterium tuberculosis H(37)Rv reference strain.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / chemical synthesis*
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology*
Antifungal Agents / chemical synthesis*
Antifungal Agents / chemistry
Antifungal Agents / pharmacology*
Candida albicans / drug effects
Hydrogen / chemistry
Imidazoles / chemical synthesis*
Imidazoles / chemistry
Imidazoles / pharmacology*
Magnetic Resonance Spectroscopy
Molecular Structure
Mycobacterium tuberculosis / drug effects
Pyrazoles / chemistry*
Structure-Activity Relationship

Substances

Anti-Bacterial Agents
Antifungal Agents
Imidazoles
Pyrazoles
pyrazole
imidazole
Hydrogen