Impact of insulin resistance on the developmental potential of immature oocytes retrieved from human chorionic gonadotropin-primed women with polycystic ovary syndrome undergoing in vitro maturation

Fertil Steril. 2009 Mar;91(3):957-9. doi: 10.1016/j.fertnstert.2007.12.062. Epub 2008 Mar 5.

Abstract

In a homeostasis model assessment-insulin resistance (HOMA-IR)-positive group of women with polycystic ovary syndrome undergoing in vitro maturation (IVM), the maturation rate of immature oocytes was significantly lower compared with a HOMA-IR negative group of women (47% vs. 59%). The results of our study showed that IR and hyperinsulinemia have an adverse effect on the developmental potential of immature oocytes retrieved in the IVM procedure.

Publication types

  • Clinical Trial
  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cells, Cultured
  • Chorionic Gonadotropin / administration & dosage*
  • Embryo Transfer
  • Female
  • Fertility Agents, Female / administration & dosage*
  • Humans
  • Hyperinsulinism / etiology*
  • Hyperinsulinism / physiopathology
  • Hyperinsulinism / therapy
  • Infertility, Female / etiology
  • Infertility, Female / physiopathology
  • Infertility, Female / therapy*
  • Insulin Resistance*
  • Models, Biological
  • Oocyte Retrieval*
  • Oogenesis / drug effects*
  • Ovulation Induction / methods*
  • Polycystic Ovary Syndrome / complications*
  • Polycystic Ovary Syndrome / physiopathology
  • Polycystic Ovary Syndrome / therapy
  • Pregnancy
  • Pregnancy Rate
  • Sperm Injections, Intracytoplasmic
  • Treatment Outcome

Substances

  • Chorionic Gonadotropin
  • Fertility Agents, Female