Abstract
In a homeostasis model assessment-insulin resistance (HOMA-IR)-positive group of women with polycystic ovary syndrome undergoing in vitro maturation (IVM), the maturation rate of immature oocytes was significantly lower compared with a HOMA-IR negative group of women (47% vs. 59%). The results of our study showed that IR and hyperinsulinemia have an adverse effect on the developmental potential of immature oocytes retrieved in the IVM procedure.
Publication types
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Clinical Trial
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Cells, Cultured
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Chorionic Gonadotropin / administration & dosage*
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Embryo Transfer
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Female
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Fertility Agents, Female / administration & dosage*
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Humans
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Hyperinsulinism / etiology*
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Hyperinsulinism / physiopathology
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Hyperinsulinism / therapy
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Infertility, Female / etiology
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Infertility, Female / physiopathology
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Infertility, Female / therapy*
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Insulin Resistance*
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Models, Biological
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Oocyte Retrieval*
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Oogenesis / drug effects*
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Ovulation Induction / methods*
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Polycystic Ovary Syndrome / complications*
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Polycystic Ovary Syndrome / physiopathology
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Polycystic Ovary Syndrome / therapy
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Pregnancy
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Pregnancy Rate
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Sperm Injections, Intracytoplasmic
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Treatment Outcome
Substances
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Chorionic Gonadotropin
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Fertility Agents, Female