CDC25A phosphatase: a rate-limiting oncogene that determines genomic stability

Cancer Res. 2008 Mar 1;68(5):1251-3. doi: 10.1158/0008-5472.CAN-07-5983.

Abstract

CDC25A is a critical regulator of cell cycle progression and checkpoint response. Overexpression of this cyclin-dependent kinase phosphatase occurs often in human cancers. Our recent genetic studies in the mouse indicate that restricting CDC25A can limit tumorigenesis induced by the HER2/neu-RAS oncogenic pathway without compromising normal cell division or viability. These findings offer a sound foundation to justify development of CDC25A inhibitors for antitumor therapy.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Cycle
  • Disease Progression
  • Gene Expression Regulation, Enzymologic*
  • Gene Expression Regulation, Neoplastic*
  • Genome
  • Genomic Instability
  • Humans
  • Mammary Neoplasms, Animal / genetics
  • Mice
  • Models, Biological
  • Neoplasms / genetics*
  • Neoplasms / metabolism*
  • Receptor, ErbB-2 / metabolism
  • cdc25 Phosphatases / chemistry
  • cdc25 Phosphatases / physiology*
  • ras Proteins / metabolism

Substances

  • Receptor, ErbB-2
  • cdc25 Phosphatases
  • ras Proteins