Pharmacological agents and impairment of fracture healing: what is the evidence?

Ippokratis Pountos; Theodora Georgouli; Taco J Blokhuis; Hans Chistoph Pape; Peter V Giannoudis

doi:10.1016/j.injury.2007.10.035

Pharmacological agents and impairment of fracture healing: what is the evidence?

Injury. 2008 Apr;39(4):384-94. doi: 10.1016/j.injury.2007.10.035. Epub 2008 Mar 7.

Authors

Ippokratis Pountos¹, Theodora Georgouli, Taco J Blokhuis, Hans Chistoph Pape, Peter V Giannoudis

Affiliation

¹ Academic Department of Trauma & Orthopaedics, School of Medicine, University of Leeds, UK.

PMID: 18316083
DOI: 10.1016/j.injury.2007.10.035

Abstract

Bone healing is an extremely complex process which depends on the coordinated action of several cell lineages on a cascade of biological events, and has always been a major medical concern. The use of several drugs such as corticosteroids, chemotherapeutic agents, non-steroidal anti-inflammatory drugs (NSAIDs), antibiotics, anticoagulants and drugs which reduce osteoclastic activity have been shown to affect bone healing. This review article presents our current understanding on this topic, focusing on data illustrating the effect of these drugs on fracture healing and bone regeneration.

Publication types

Review

MeSH terms

Adrenal Cortex Hormones / adverse effects
Adrenal Cortex Hormones / pharmacology
Animals
Anti-Inflammatory Agents, Non-Steroidal / adverse effects
Anti-Inflammatory Agents, Non-Steroidal / pharmacology
Anticoagulants / adverse effects
Anticoagulants / pharmacology
Bone Regeneration / drug effects*
Bony Callus / drug effects*
Diphosphonates / adverse effects
Diphosphonates / pharmacology
Disease Models, Animal
Evidence-Based Medicine
Fracture Healing / drug effects*
Fracture Healing / physiology
Humans
Osteogenesis / drug effects

Substances

Adrenal Cortex Hormones
Anti-Inflammatory Agents, Non-Steroidal
Anticoagulants
Diphosphonates