Ghrelin gets its GOAT

Cell Metab. 2008 Mar;7(3):193-4. doi: 10.1016/j.cmet.2008.02.009.

Abstract

Ghrelin, a powerful appetite-stimulating hormone secreted by the stomach, is modified by an octanyl side chain on its third amino acid, a serine, which is essential for its activity. A recent study (Yang et al., 2008) reports identification of the enzyme catalyzing the addition of this octanyl, GOAT.

MeSH terms

  • Acyltransferases / antagonists & inhibitors
  • Acyltransferases / metabolism*
  • Animals
  • Appetite Regulation* / drug effects
  • Cell Line
  • Cloning, Molecular
  • Enzyme Inhibitors / pharmacology
  • Ghrelin / metabolism*
  • Humans
  • Membrane Proteins
  • Mice
  • Receptors, Ghrelin / metabolism
  • Recombinant Proteins / metabolism
  • Serine / metabolism

Substances

  • Enzyme Inhibitors
  • Ghrelin
  • Membrane Proteins
  • Receptors, Ghrelin
  • Recombinant Proteins
  • ghrelin, des-n-octanoyl
  • Serine
  • Acyltransferases
  • Mboat4 protein, mouse