[Use of zoledromic acid on pain control in stages M1b of prostate cancer]

Actas Urol Esp. 2007 Nov-Dec;31(10):1100-6. doi: 10.1016/s0210-4806(07)73771-3.
[Article in Spanish]

Abstract

Objectives: To probe the use of Zoledromic acid in the control of the pain due to bone methastasis of a prostate cancer.

Material and method: We included in our study 37 consecutive patients diagnosed of prostate cancer who developed bone methastasis during 2005 and 2006 to whom we gave a 4 mg dose of Zoledromic acid during a mean time of 10.24 months.

Results: We observed a complete control of the pain in 8 of the 20 patients, and partially in 6 of those patients. We did not evaluate any adverse reaction due to this treatment.

Conclusions: We still yet to know whether the administration of this treatment in the early stages of the prostate cancer could prevent or retard the appearance of bone methastasis.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Bone Density Conservation Agents / therapeutic use*
  • Bone Neoplasms / complications*
  • Bone Neoplasms / secondary*
  • Diphosphonates / therapeutic use*
  • Humans
  • Imidazoles / therapeutic use*
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Pain / drug therapy*
  • Pain / etiology
  • Prostatic Neoplasms / pathology
  • Zoledronic Acid

Substances

  • Bone Density Conservation Agents
  • Diphosphonates
  • Imidazoles
  • Zoledronic Acid