CT colonography (CTC) is an innovative technology that entails CT examination of the entire colon and computerized processing of the raw data after colon cleansing and colonic distention. CTC could potentially increase the screening rate for colon cancer because of its relative safety, relatively low expense, and greater patient acceptance, but its role in mass colon cancer screening is controversial because of its highly variable sensitivity, the inability to sample polyps for histologic analysis, and lack of therapeutic capabilities. This article reviews the CTC literature, including imaging and adjunctive techniques, radiologic interpretation, procedure indications, contraindications, risks, sensitivity, interpretation pitfalls, and controversies.