Type I interferon response to cytomegalovirus infection: the kick-start

Cell Host Microbe. 2008 Feb 14;3(2):59-61. doi: 10.1016/j.chom.2008.01.005.

Abstract

Host responses to cytomegalovirus infection include initial early production of alpha and beta interferons, also called type I interferons, which are elicited directly by viral products via Toll-like receptors. New data indicate that, preceding these events, an earlier critical type I interferon elicited in primary infected stromal cells via the lymphotoxin beta receptor system and mediated by B cells is necessary to kick-start an efficient antiviral response.

Publication types

  • Comment
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • B-Lymphocytes / metabolism
  • Cytomegalovirus Infections / immunology*
  • Interferon Type I / immunology*
  • Lymphotoxin alpha1, beta2 Heterotrimer / metabolism
  • Lymphotoxin beta Receptor / metabolism
  • Mice
  • Muromegalovirus / immunology*
  • Stromal Cells / immunology
  • Stromal Cells / metabolism
  • Toll-Like Receptors / metabolism

Substances

  • Interferon Type I
  • Lymphotoxin alpha1, beta2 Heterotrimer
  • Lymphotoxin beta Receptor
  • Toll-Like Receptors