Abstract
Tritylated tetrazole of 2a underwent unusual detritylation under basic reaction condition during the synthesis of methyl ether of olmesartan medoxomil 1. The unusual detritylation was found to be a common feature in the case of all tetrazole containing Sartan molecules (3-7).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Angiotensin II Type 1 Receptor Blockers / chemistry*
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Chromatography, Thin Layer
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Imidazoles / chemistry
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Isotope Labeling
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Tetrazoles / chemistry*
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Tritium / chemistry
Substances
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Angiotensin II Type 1 Receptor Blockers
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Imidazoles
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Tetrazoles
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Tritium
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olmesartan