Unusual detritylation of tritylated tetrazole in Sartan molecules

Chem Pharm Bull (Tokyo). 2008 Mar;56(3):383-4. doi: 10.1248/cpb.56.383.

Abstract

Tritylated tetrazole of 2a underwent unusual detritylation under basic reaction condition during the synthesis of methyl ether of olmesartan medoxomil 1. The unusual detritylation was found to be a common feature in the case of all tetrazole containing Sartan molecules (3-7).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiotensin II Type 1 Receptor Blockers / chemistry*
  • Chromatography, Thin Layer
  • Imidazoles / chemistry
  • Isotope Labeling
  • Tetrazoles / chemistry*
  • Tritium / chemistry

Substances

  • Angiotensin II Type 1 Receptor Blockers
  • Imidazoles
  • Tetrazoles
  • Tritium
  • olmesartan