Daptomycin use in infants: report of two cases with peak and trough drug concentrations

J Perinatol. 2008 Mar;28(3):233-4. doi: 10.1038/sj.jp.7211898.

Abstract

We report two infants treated with daptomycin for methicillin-resistant Staphylococcus aureus infection and describe peak and trough blood concentrations measured during therapy. The peak concentrations were 41.7 and 36.7 mcg ml(-1), and the 12-hour trough concentrations were 12.7 and 16.3 mcg ml(-1), respectively. Even though the infants received higher doses than adults, their drug concentrations were comparable to those observed in adults treated with regular dosing of daptomycin.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacokinetics*
  • Bacteremia / drug therapy*
  • Bacteremia / microbiology
  • Daptomycin / pharmacokinetics*
  • Drug Monitoring / methods
  • Humans
  • Infant
  • Infant, Newborn
  • Infant, Premature
  • Methicillin Resistance / drug effects*
  • Staphylococcal Infections / drug therapy*
  • Staphylococcus aureus / drug effects*
  • Staphylococcus aureus / pathogenicity

Substances

  • Anti-Bacterial Agents
  • Daptomycin