Glycosides from the bark of Adina polycephala

Yanling Zhang; Maoluo Gan; Sheng Lin; Mingtao Liu; Weixia Song; Jiachen Zi; Sujuan Wang; Shuai Li; Yongchun Yang; Jiangong Shi

doi:10.1021/np700758q

Glycosides from the bark of Adina polycephala

J Nat Prod. 2008 May;71(5):905-9. doi: 10.1021/np700758q. Epub 2008 Feb 28.

Authors

Yanling Zhang¹, Maoluo Gan, Sheng Lin, Mingtao Liu, Weixia Song, Jiachen Zi, Sujuan Wang, Shuai Li, Yongchun Yang, Jiangong Shi

Affiliation

¹ Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College (Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education), Beijing, PR China.

PMID: 18303851
DOI: 10.1021/np700758q

Abstract

Four new dimeric phenolic glycosides (1- 4), a new iridoid diglycoside (5), and 15 known glycosides have been isolated from an ethanolic extract of the bark of Adina polycephala. Their structures were determined by spectroscopic and chemical methods. Compounds 1, 3, and 5 showed in vitro inhibitory activity against the release of beta-glucuronidase in rat polymorphonuclear leukocytes induced by platelet-activating factor.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Drugs, Chinese Herbal / chemistry
Drugs, Chinese Herbal / isolation & purification*
Drugs, Chinese Herbal / pharmacology
Glucuronidase / drug effects
Glucuronidase / metabolism
Glycosides / chemistry
Glycosides / isolation & purification*
Glycosides / pharmacology
Iridoids / chemistry
Iridoids / isolation & purification*
Iridoids / pharmacology
Molecular Structure
Neutrophils / drug effects
Neutrophils / enzymology
Nuclear Magnetic Resonance, Biomolecular
Plant Bark / chemistry
Plants, Medicinal / chemistry*
Platelet Activating Factor / pharmacology
Rats
Rubiaceae / chemistry*

Substances

Drugs, Chinese Herbal
Glycosides
Iridoids
Platelet Activating Factor
Glucuronidase