Abstract
Daptomycin pharmacokinetics were evaluated for burn patients. Burn patients had decreases in the maximum concentration of the drug in serum (44%) and the area under the concentration-time curve (47%) and increases in the volume of distribution (64%) and total clearance (77%) compared to healthy volunteers. In burn patients, daptomycin at 10 to 12 mg/kg of body weight/day would be required to achieve drug exposures similar to those for healthy volunteers receiving 6 mg/kg.
Publication types
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Clinical Trial
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Anti-Bacterial Agents / blood
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Anti-Bacterial Agents / pharmacokinetics
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Anti-Bacterial Agents / urine
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Area Under Curve
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Burns / drug therapy*
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Burns / metabolism
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Chromatography, High Pressure Liquid
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Daptomycin / blood
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Daptomycin / pharmacokinetics*
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Daptomycin / urine
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Female
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Humans
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Male
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Metabolic Clearance Rate
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Middle Aged
Substances
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Anti-Bacterial Agents
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Daptomycin