Within the variety of diseases in which there is an excessive production of immunoglobulin E (IgE), clinicians have the dilemma to establish a differential diagnosis between allergy, immunodeficiency and even autoimmunity. In the present study the clinical manifestations of allergic patients who presented very high levels of IgE and who were taken care of in the Allergy Service of the National Institute of Pediatrics and did not show criteria to be identified as carriers of some non-atopic immunological disease (eg. Hyper-IgE syndrome), are described. In addition, the regulation and synthesis of IgE is presented. The authors propose that the presence of an allergic entity with or without skin manifestations without any history of recurrent infections or cutaneous abscesses, should be named allergic disease with hypersynthesis of IgE, in which the levels of IgE are greater than 2,000 UI/mL.