Objective: To investigate the effect of intralesional Pingyangmycin injection in venous malformation of facial and maxillary region.
Materials and methods: From September 2001 to October 2004, 82 patients were referred with venous malformation for intralesional Pingyangmycin injection.
Results: After a minimum follow-up of 2 years, 67 patients (81.7%) developed 76-100% regression in their lesions; 12 patients (14.6%) had 51-75% regression in their lesion; 3 patients underwent surgical excision for the residual swellings. No changes in renal function or cytopenias were encountered. No patients developed chest X-ray changes during the course of therapy. There were no mortalities.
Conclusion: Intralesional injection of Pingyangmycin is an effective, inexpensive, and safe method in venous malformation of facial and maxillary region. We now favor Pingyangmycin sclerotherapy before considering surgical excision in all cases of venous malformation in our hospital.