[Synthesis and antimicrobial activity of some new (sulfon-amidophenyl)-amide derivatives of N-(m-nitrobenzoyl)-D,L-methionine]

Rev Med Chir Soc Med Nat Iasi. 2007 Jul-Sep;111(3):773-8.
[Article in Romanian]

Abstract

In order to obtain new compounds with potential antimicrobial activity some new (sulfon-amidophenyl)-amide derivatives of N-(m-nitrobenzoil)-D,L-methionine have been synthesized. The compounds have been obtained by decyclization reaction of 2-(m-nitrophenyl)-4-(beta-P-methylthioethyl)- delta2-5-oxazolinone with various sulfonamides. The chemical structure of the new sulfonamides was confirmed by elemental analysis data and IR and 1NMR spectral measurements. The compounds were also investigated for their antimicrobial activity using Staphylococcus aureus, Escherichia coli, Listeria monocytogenes and Proteus vulgaris strains.

MeSH terms

  • Anti-Bacterial Agents / chemical synthesis*
  • Anti-Bacterial Agents / pharmacology*
  • Escherichia coli / drug effects
  • Humans
  • Listeria monocytogenes / drug effects
  • Mass Spectrometry
  • Methionine / analogs & derivatives*
  • Methionine / biosynthesis*
  • Microbial Sensitivity Tests / methods
  • Proteus vulgaris / drug effects
  • Staphylococcus aureus / drug effects
  • Sulfonamides / chemical synthesis*

Substances

  • Anti-Bacterial Agents
  • Sulfonamides
  • Methionine