Abstract
The composition of the volatile oil obtained by hydrodistillation from the fruit peel of Garcinia brasiliensis (Mart.) Planch. et Triana was determined by GC/MS. A total of 38 components were identified, including gamma-muurolene (10.3%), spathulenol (8.7%), delta-cadinene (8.3%), torreyol (8.0%), alpha-cadinol (7.0%), cadalene (6.3%), and gamma-cadinene (5.3%). Oxygenated sesquiterpenes (43%) were the main group of compounds. The anti-inflammatory activity of the volatile oil was evaluated through the rat-paw edema model induced by carrageenan. Inhibition of the inflammatory process was noticed 3 h after carrageenan administration. In addition, the volatile oil showed poor antioxidant activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents / chemistry*
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Anti-Inflammatory Agents / pharmacology
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Anti-Inflammatory Agents / therapeutic use
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Antioxidants / chemistry*
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Antioxidants / isolation & purification
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Antioxidants / pharmacology
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Carrageenan / administration & dosage
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Disease Models, Animal
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Edema / chemically induced
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Edema / drug therapy
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Free Radical Scavengers / chemistry
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Free Radical Scavengers / isolation & purification
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Free Radical Scavengers / pharmacology
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Fruit / chemistry*
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Garcinia / chemistry*
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Gas Chromatography-Mass Spectrometry / methods
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Inflammation / chemically induced
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Inflammation / drug therapy
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Oils, Volatile / chemistry*
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Oils, Volatile / pharmacology
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Oils, Volatile / therapeutic use
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Oxidation-Reduction
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Plant Extracts / chemistry*
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology
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Rats
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification
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Sesquiterpenes / pharmacology
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Time Factors
Substances
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Anti-Inflammatory Agents
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Antioxidants
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Free Radical Scavengers
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Oils, Volatile
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Plant Extracts
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Sesquiterpenes
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Carrageenan