Toward the pathway of S. aureus WTA biosynthesis

Guoqing Xia; Andreas Peschel

doi:10.1016/j.chembiol.2008.02.005

Toward the pathway of S. aureus WTA biosynthesis

Chem Biol. 2008 Feb;15(2):95-6. doi: 10.1016/j.chembiol.2008.02.005.

Authors

Guoqing Xia¹, Andreas Peschel

Affiliation

¹ Cellular and Molecular Microbiology Section, Medical Microbiology and Hygiene Department, University of Tübingen, Elfriede-Aulhorn-Strasse 6, 72076 Tübingen, Germany.

PMID: 18291312
DOI: 10.1016/j.chembiol.2008.02.005

Abstract

Wall teichoic acid (WTA) contributes profoundly to the virulence of Staphylococcus aureus. The successful in vitro reconstitution of poly-ribitolphosphate WTA biosynthesis using recombinant enzymes sheds new light on WTA enzymology and paves the way for developing new antibiotics that target WTA biosynthesis, as discussed in Brown et al. in a recent issue of Chemistry & Biology.

MeSH terms

Anti-Bacterial Agents / pharmacology
Cell Wall / drug effects
Cell Wall / metabolism*
Multigene Family
Staphylococcus aureus / cytology
Staphylococcus aureus / drug effects
Staphylococcus aureus / genetics
Staphylococcus aureus / metabolism*
Teichoic Acids / biosynthesis*

Substances

Anti-Bacterial Agents
Teichoic Acids