The kinetics and molecular modeling of the complexation of tenoxicam with cyclodextrins in solution

Abdelmonem Rawashdeh; Shehadeh Mizyed; Sabri Mahmoud; Deeb Marji

doi:10.1016/j.saa.2007.12.046

The kinetics and molecular modeling of the complexation of tenoxicam with cyclodextrins in solution

Spectrochim Acta A Mol Biomol Spectrosc. 2008 Nov 15;71(2):562-5. doi: 10.1016/j.saa.2007.12.046. Epub 2008 Jan 17.

Authors

Abdelmonem Rawashdeh¹, Shehadeh Mizyed, Sabri Mahmoud, Deeb Marji

Affiliation

¹ Chemistry Department, Yarmouk University, Irbid, Jordan.

PMID: 18289928
DOI: 10.1016/j.saa.2007.12.046

Abstract

The effect of cyclodextrins on photodegradation of tenoxicam (TEN) was studied at pH 4, 7 and 10. After 60 min of irradiation with UV light, the photodegradation was extensive. All cyclodextrins (alpha, beta, or gamma) stabilize TEN and reduce the rate of photodegradation. The largest effect of cyclodextrins is at pH 7. Molecular modeling results help to explain and manipulate the results. The results are discussed and compared with other results from previous studies.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Computer Simulation
Cyclodextrins / chemistry*
Hydrogen-Ion Concentration
Kinetics
Models, Molecular*
Molecular Structure
Photochemistry
Piroxicam / analogs & derivatives*
Piroxicam / chemistry
Solutions

Substances

Cyclodextrins
Solutions
Piroxicam
tenoxicam