Abstract
Chalcone derivatives of the natural product khellinone were synthesised and screened for bioactivity against the voltage-gated potassium channel Kv1.3. X-ray crystallography was employed to investigate relationships between the structure and function of a selection of the reported chalcones.
Publication types
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Evaluation Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Benzofurans / pharmacology
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Chalcones / chemical synthesis*
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Chalcones / chemistry
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Chalcones / pharmacology*
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Crystallography, X-Ray
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Electrophysiology
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Humans
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Kv1.3 Potassium Channel / antagonists & inhibitors*
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Kv1.3 Potassium Channel / metabolism
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Models, Chemical
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Molecular Structure
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Potassium Channel Blockers / chemical synthesis*
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Potassium Channel Blockers / chemistry
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Potassium Channel Blockers / pharmacology*
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Structure-Activity Relationship
Substances
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Benzofurans
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Chalcones
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Kv1.3 Potassium Channel
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Potassium Channel Blockers
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khellinone