Abstract
Utilizing different computational methods; phosphorylation, O-GlcNAc modification and Yin Yang sites are predicted in HMGN-1. Prediction results suggest that interplay of phosphorylation and O-GlcNAc modification regulates binding and removal of HMGN-1 with the nucleosome and its translocation from nucleus to cytoplasm and back to nucleus, consequently modulating gene expression.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetylglucosamine / chemistry*
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Acetylglucosamine / metabolism
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Active Transport, Cell Nucleus / physiology
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Amino Acid Sequence
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Animals
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Cell Nucleus / metabolism
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Computer Simulation
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Cytoplasm / metabolism
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Gene Expression Regulation*
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HMGN1 Protein* / chemistry
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HMGN1 Protein* / genetics
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HMGN1 Protein* / metabolism
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Histones / metabolism*
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Humans
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Molecular Sequence Data
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Nucleosomes / metabolism
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Phosphorylation
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Protein Binding
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Protein Processing, Post-Translational*
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Sequence Alignment
Substances
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HMGN1 Protein
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Histones
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Nucleosomes
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Acetylglucosamine